Abstract
Objective: E-cigarette products have resulted in various controversies concerning their posed impacts on health. Some argue that exposure to e-cigarette smoke could improve free radicals in the body; thus, it causes harming impacts on health. Peroral selenium (Se) administration can increase superoxide dismutase (SOD) and glutathione peroxidase (GPx) serving as antioxidants in the body.
 Methods: This research is an experimental study aiming to analyze the effectiveness of Se to decrease free radical due to exposure to e-cigarette smoke as one of the preventive actions. The research was carried out to male Wistar rats with exposure to e-cigarette smoke and peroral Se intake with different time and duration of administration.
 Results: Research results showed a decrease of antioxidant SOD and GPx in the administration of exposure to e-cigarette smoke, and they gradually increased after Se administration (p=0.000). Meanwhile, the malondialdehyde level was inversely proportional compared to antioxidant SOD and GPx.
 Conclusion: Se is a micronutrient that can reduce free radicals due to exposure to e-cigarette smoke through enhancement of antioxidant enzymes such as SOD and GPx.
Highlights
The use of electronic cigarettes keeps on increasing annually
Even in passive smokers inhaling the smoke of e-cigarettes, nicotine is found in blood [4]
superoxide dismutase (SOD) levels in blood as a result of exposure to e-cigarette smoke Research results were obtained by comparing the levels of SOD in each group
Summary
The use of electronic cigarettes keeps on increasing annually. It is caused by the absence of specific regulations targeting the use of e-cigarettes leading to their use at any place [1]. Their great shapes and models compared to tobacco cigarettes along with their massive promotion attract young people [2]. Electronic cigarettes are claimed as tools to reduce or stop the use of tobacco cigarettes They are considered to be safer and have less risk because they only produce water vapor claimed not to endanger health [3]. The amount enhancement of excessive free radicals will cause amount imbalance of free radicals and antioxidants in the body so that oxidative stress occurs [5]
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