Abstract

Introduction: Oxidative stress is believed to play a major role in the development of, among others, immunologic diseases. Asthma is a chronic allergic airway disease, and to date it is not clear whether the observed enhanced oxidative stress in asthmatic patients is caused by airway inflammation, or is a causative factor in the pathogenesis of this disease. Several studies have attributed the thioredoxin fold family a major impact in protection of the lung, and deregulation may bring about initiation of Th2-dominant immunity and contribute to the progression or perpetuation of existing airway inflammation. This project will investigate the role of selected redoxins with focus on thioredoxins (Trxs), glutaredoxins (Grxs) and peroxiredoxins (Prxs).

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