Abstract

The rapid spread of the new SARS-CoV-2 virus triggered a global health crisis, disproportionately impacting people with pre-existing health conditions and particular demographic and socioeconomic characteristics. One of the main concerns of governments has been to avoid health systems becoming overwhelmed. For this reason, they have implemented a series of non-pharmaceutical measures to control the spread of the virus, with mass tests being one of the most effective controls. To date, public health officials continue to promote some of these measures, mainly due to delays in mass vaccination and the emergence of new virus strains. In this research, we studied the association between COVID-19 positivity rate and hospitalization rates at the county level in California using a mixed linear model. The analysis was performed in the three waves of confirmed COVID-19 cases registered in the state to September 2021. Our findings suggest that test positivity rate is consistently associated with hospitalization rates at the county level for all study waves. Demographic factors that seem to be related to higher hospitalization rates changed over time, as the profile of the pandemic impacted different fractions of the population in counties across California.

Highlights

  • The SARS-CoV-2 virus, responsible for the novel coronavirus disease (COVID-19), was identified in late December 2019 in Wuhan, China [1], and spread rapidly, causing a global health crisis

  • Counties with high proportions of Hispanic or Latino and African American populations were not significantly different, but a 3.4% increase in hospitalization rates was associated with every 1% of the population that identifies as Asian

  • A mixed linear model was used between the COVID-19 hospitalization rate and factors such as age, ethnicity, race, poverty index, and intra-community mobility

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Summary

Introduction

The SARS-CoV-2 virus, responsible for the novel coronavirus disease (COVID-19), was identified in late December 2019 in Wuhan, China [1], and spread rapidly, causing a global health crisis. As the pandemic spread across the globe, governments started to enforce public policies to suppress SARS-CoV-2 transmission, including social distancing, contact tracing, stay-at-home orders, school closings, limited public space utilization, and border closures [3,4]. Public health officials continue to promote some of these non-pharmaceutical measures, mainly due to delays in mass vaccination and the growing number of new COVID-19 variants [5]. Efforts of isolation, quarantine, and contact tracing became essential control measures for curtailing the burden of the COVID-19 pandemic [6]. The successful epidemic control measures taken by countries such as Korea, Taiwan, Japan, China, New Zealand, and the Czech

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