Abstract
BackgroundSurgical site infection describes an infectious complication of surgical wounds. This single complication is thought to occur in close to 20% of surgical cases. This complication has been described in all kinds of surgical procedure including minimally invasive procedures. Wound irrigation is frequently used as a means of reducing surgical site infection. However, there is lack of solid evidence to support routine wound irrigation. The aim of this review is to provide evidence for the efficacy of routine wound irrigation with normal saline in preventing surgical site infection. The rate of surgical site infection in cases with and without wound irrigation will be analyzed.Methods/designSystematic literature searches will be conducted to identify all published and unpublished studies. The following databases will be searched for citations from inception to present: MEDLINE (via PubMed), Embase (via Embase), and CENTRAL (via the Cochrane library). The search strategy will be developed by the research team in collaboration with an experienced librarian and checked by a referee according to the Peer Review of Electronic Search Strategies (PRESS) guideline. A draft of the PubMed search strategy could be (irrigation[tiab] OR “Therapeutic Irrigation”[mesh] OR lavage[tiab]) AND (saline[tiab] OR “Sodium Chloride”[mesh] OR sodium chloride[tiab]) NOT (“Comment” [Publication Type] OR “Letter” [Publication Type] OR “Editorial” [Publication Type]). No time limits will be set. The reference lists of eligible articles will be hand searched. Relevant data will be extracted from eligible studies using a previously designed data extraction sheet. Relative risks will be calculated for binary outcomes and mean differences or standardized mean differences, if necessary, for continuous outcomes. For all measures, 95% confidence levels will be calculated. Both arms would be compared with regard to the rate of surgical site infection within 30 days following surgery. We will report the review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.DiscussionThis review aims at investigating the value of routine wound irrigation using normal saline in preventing surgical site infection.Systematic review registrationPROSPERO: CRD42018082287
Highlights
Rationale According to the World Health Organization (WHO), healthcare-associated infections (HAIs) acquired by patients when receiving care is the most frequent adverse event worldwide
This review aims at investigating the value of routine wound irrigation using normal saline in preventing surgical site infection
We aim to investigate the efficacy of Wound irrigation (WI) with normal saline in reducing surgical site infection
Summary
Rationale According to the World Health Organization (WHO), healthcare-associated infections (HAIs) acquired by patients when receiving care is the most frequent adverse event worldwide. Surgical site infection (SSI) describes an infectious complication of surgical wounds. The use of prophylactic single-shot antibiotics at the beginning of surgery prior to skin incision, minimally invasive access with less tissue trauma, and the use of wound protectors have been described as means of reducing SSI [5, 9,10,11]. Surgical site infection describes an infectious complication of surgical wounds This single complication is thought to occur in close to 20% of surgical cases. This complication has been described in all kinds of surgical procedure including minimally invasive procedures. The aim of this review is to provide evidence for the efficacy of routine wound irrigation with normal saline in preventing surgical site infection. The rate of surgical site infection in cases with and without wound irrigation will be analyzed
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