Abstract
We previously reported that oxidation of RyR2 caused formation of disulfide bonds between two subunits within the channel - intersubunit cross-linking (XL). Because intersubunit dynamics within the RyR2 determines the channel gating, XL should play an important role in RyR2 regulation. We found a strong positive correlation between the degree of RyR2 XL and sarcoplasmic reticulum (SR) Ca leak in rabbit ventricular myocytes. When the XL reached the maximum level, further oxidation of RyR2 did not enhance SR Ca leak.
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