Abstract
The role of Robo receptors in cortical interneuron migration
Highlights
We have been investigating the molecular mechanisms that guide the migration of cortical interneurons from their origin in the subpallial ganglionic eminences (GE) to the neocortex
Earlier studies have suggested that cortical interneurons express neuropilin (Nrp) receptors, which enable them to respond to the chemorepulsion produced by class 3 semaphorins (Sema3A and Sema3F) expressed in the striatum
Our recent studies have indicated that Robo1 controls the migration of cortical interneurons by modulating their responsiveness to semaphorins
Summary
We have been investigating the molecular mechanisms that guide the migration of cortical interneurons from their origin in the subpallial ganglionic eminences (GE) to the neocortex. THE ROLE OF ROBO RECEPTORS IN CORTICAL INTERNEURON MIGRATION John G Parnavelas Department of Cell and Developmental Biology, University College London, UK
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