Abstract
Contaminated food is the source of many severe infections in humans. Recent advances in food science have discovered new foodborne pathogens and progressed in characterizing their biology, life cycle, and infection processes. All this knowledge has been contributing to prevent food contamination, and to develop new therapeutics to treat the infections caused by these pathogens. RNA metabolism is a crucial biological process and has an enormous potential to offer new strategies to fight foodborne pathogens. In this review, we will summarize what is known about the role of bacterial ribonucleases and sRNAs in the virulence of several foodborne pathogens and how can we use that knowledge to prevent infection.
Highlights
Globalization has important implications for food safety considering the exchanging of food around the world
The aim of this review is to provide a broad look to what is known about the role of bacterial ribonucleases and small non-coding RNAs (sRNAs) in virulence of several foodborne pathogens and discuss their potential for the development of new therapeutic applications
In C. jejuni, RNase R was shown to be active in a wide range of conditions, which could be crucial for the adaptation during the infection process
Summary
Globalization has important implications for food safety considering the exchanging of food around the world. Scientists are making great progresses in securing food by studying the biology, life cycles, and infection processes of foodborne pathogens. Ribonucleases (RNases) are crucial enzymes for the cell, since they degrade RNA and are involved in the processing and quality control of transcripts (Arraiano et al, 2010). The discovery of small non-coding RNAs (sRNAs) unraveled a new world of post-transcriptional regulatory networks, which cooperate with RNases in the control of gene expression. With the development of new technologies, many sRNA molecules were identified and shown to be important players in bacterial virulence. The aim of this review is to provide a broad look to what is known about the role of bacterial ribonucleases and sRNAs in virulence of several foodborne pathogens and discuss their potential for the development of new therapeutic applications
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