Abstract
The DEREG transgenic mouse allows for selective depletion of regulatory T cells (Treg) in vivo when treated with diphtheria toxin (DT). While this mouse is widely used to study the role of Tregs in immune homeostasis, studies on its application to pregnancy immune tolerance are limited. We sought to analyze Treg depletion and recovery kinetics in to order find a DT dose that balanced interruption of Treg function with risk for autoimmunity. Additionally, we evaluated the impact of Treg depletion during syngeneic pregnancy when only male pups are antigenic.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
