The Role of Red Blood Cell Distribution Width in the Severity and Prognosis of Community-Acquired Pneumonia.

Qiang Ren,Guiwei Jiao,Xiaomin Liu,Hebing Liu,Zhennan Tian,Ying Wang,Deyu Dai,Haiyan Yin

doi:10.1155/2021/8024024

Abstract

Objectives The objective of this study is to unravel the correlation between RDW and the severity and prognosis of CAP, as well as exploring RDW with the inflammatory markers white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT). Methods According to the data characteristics, appropriate statistical methods were selected to analyze the relationship between RDW and the severity and prognosis of CAP patients and to determine whether RDW is associated with the inflammatory markers WBC, CRP, and PCT. Results The results show that with the increase of PSI and CURB-65 values, the proportion of patients with RDW ≥ 12.987% is significantly higher than that of RDW < 12.987% (P < 0.01). When RDW is combined with PSI or CURB-65 to predict the 90-day mortality of CAP patients, the area under the receiver operating characteristic (ROC) curve increased prominently, and if RDW, PSI, and CURB-65 are combined, the area under the ROC curve is maximized. Conclusions Our findings suggest that the higher RDW value is associated with short-term adverse outcomes in CAP patients. We also find that when RDW, PSI, and CURB-65 are combined, the best performance is achieved to predict CAP 90-day mortality risk.

Highlights

Community-acquired pneumonia (CAP) refers to the infectious pulmonary parenchymal inflammation acquired outside the hospital, and it is a worldwide public health problem
Studies have shown a mortality rate of less than 5% in outpatient CAP patients, more than 10% in hospitalized patients, and 30%if patients need to be admitted to the intensive care unit [1, 2]. erefore, in the management of CAP, early identification of high-risk patients with poor prognosis is critical [3]. e widespread use of CAP severity assessment scales such as Pneumonia Severity Index (PSI) and CURB-65 has largely solved the problem of risk stratification, but it has its own limitations
A retrospective study is conducted on 3278 patients who met the screening criteria in our hospital from the collection period. e mean red blood cell distribution width (RDW) of the sample is 12.987%, and all patients are divided into two groups according to the mean (Table 1)

Summary

Introduction

Community-acquired pneumonia (CAP) refers to the infectious pulmonary parenchymal inflammation acquired outside the hospital, and it is a worldwide public health problem. A number of studies have shown that the scores of PSI and CURB-65 in CAP patients with higher RDW values tend to be higher, and the higher the score level, the more severe the condition [26].

Results

Conclusion