Abstract
Introduction: Colorectal cancer (CRC) remains the second most frequent cause of cancer-related mortality in the United States. The majority of these deaths are secondary to metastatic disease. Emerging data suggest the idea that RKIP is a metastasis suppressor. The loss of RKIP expression has been reported to be a marker of CRC progression and metastasis. Despite this correlation, the mechanism of RKIP inhibition of CRC metastasis remains undefined. We hypothesize that RKIP expression directly inhibits cell invasion and metastasis by regulating the MAPK/ERK signaling pathway.
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