Abstract
Purpose: The prostate is composed of four main areas: anterior fibrous septal area, transition zone (TZ), peripheral zone (PZ) and central zone (CZ), with more than 95% of tumours located in PZ and TZ [1,2]. Each zone has variable tumour incidence, with patients diagnosed with TZ tumours having a better prognosis than PZ and CZ tumours [3,4]. Recent molecular and histopathological studies have shown that unique zonal features may contribute to the diverse patient outcome carrying tumours arising from each prostate zone [3–5]. This study aims to understand the precise cellular composition of the prostate zones and their functional contribution to tumour progression. We first aim to define the cellular composition of the prostate zones, focusing on the epithelial tumour cells and their microenvironment.
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