Abstract
Preterm birth complicates 10-12% of pregnancies worldwide with significant economic and healthcare burdens. Progesterone is necessary to establish and maintain pregnancy. Humans undergo a functional progesterone withdrawal for initiation of labor, possibly due to changes in the ratio progesterone receptor isoforms PRA and PRB, as there is an increase in the PRA/PRB ratio at the time of labor. Our goal is to determine the role of these PR isoforms in the maintenance of pregnancy by altering the isoform ratio in the mouse myometrium.
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