Abstract
Objective: To identify the most effective primary preventive interventions for reducing the disease burden of HCV infection in Pakistan. Study Design: Literature Review. Methods: A comprehensive review of the published literature on the effectiveness of primary prevention interventions to reduce the incidence and prevalence of HCV infection was undertaken by using the scientific data bases. Results: The review identified 15 relevant studies. These studies identified the key risk factors responsible for high disease burden of HCV infection in Pakistan, that is, therapeutic injections, unsafe medical/surgical practices, needle stick injuries, unscreened blood transfusions, poor knowledge and risk awareness. Conclusion: There is an immense need of further research and pragmatic guidance for policy makers to evaluate the effectiveness of primary prevention in reducing the transmission of HCV infection. The government of Pakistan and main health authorities should intervene more effectively to control the high rates of HCV infection. Safe injection practices along with safe medical/surgical practices; safe blood supply and risk awareness among the general population should be the main priorities for preventing the spread of HCV infection in Pakistan.
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