Abstract
The assessment for PET negative nodules has not been determined yet. We try to determine the role of the PET negative nodules for the patients of colorectal liver metastasis. (subjects and methods) 126 patients who underwent PET before hepatectomy at our hospital between 2005 and 2017. In these cases, the effect of NAC, the disease free survival rate (DFS) and overall survival rate (OS) were examined, and the characteristics were compared and investigated in 49 patients who underwent NAC and 77 cases who didn't receive NAC. (Results) PET negative patients were 34patients (114 nodules) out of 49 patients (197 nodules). 160 nodules out of 197 nodules were resected and 37 nodules were follow up. A viable tumor was found in 147 nodules of 160 resected nodules, and 27 nodules out of 37 nodules which were observed were relapsed. Total 174 nodules were determined to be viable tumors. Among the 34 recurrent patients, 18 patients relapsed due to relapse of PET negative nodules, 7 patients due to the appearance of new nodules and 4 patients due to the other organ metastasis. Relapse of PET negative nodules occurred around 276 days on the other hand, 410days in the patients of appearance of new nodules. DFS and OS were prolonged in the patients of relapse of PET-negative nodules compared with other recurrent patients (Discussion) Even PET revealed negative, viable cells remain in most of the tumors. (Conclusion) it is desirable to resect all tumors even the tumor showed PET negative.
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