Abstract
Using an experimental model of hypersensitivity pneumonitis in rabbits wherein depressions in arterial ozygen tension are monitored following aerosol challenge with antigen, an attempt was made to determine the effect of humoral antibody on the pulmonary physiologic impairment. Rabbits that had been passively immunized with large quantities of anti-human serum albumin (HSA) serum failed to respond with depressions in Pa 02 following aerosol challenge with antigen as opposed to actively immunized animals. Rabbits that were actively immunized with HSA by the aerosol route did respond with various patterns of pulmonary physiologic impairment with time following subsequent challenge, but these defects could not be correlated with the presence of precipitins.
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