Abstract
Background Resveratrol (RSV) is polyphenol present in various kinds of food which we consume on daily basis. In the last ten years there has been growing importance of RSV in the literature. It is well known that RSV has many different beneficial effects on human health. RSV is partly responsible for the cardiovascular benefits of red wine. However, the mechanism of vasodilatation induced by RSV is unclear. There are many target molecules of RSV which could play an important role in the mechanism of action of RSV. The aim of our study was to define the role of K channels in the RSV-induced vasodilatation of human umbilical vein (HUV) denuded of endothelium.
Highlights
Resveratrol (RSV) is polyphenol present in various kinds of food which we consume on daily basis
The role of potassium channels in the mechanism of vasodilatation of human umbilical vein induced by resveratrol
Concentrations of RSV above 10 μM relaxed human umbilical vein (HUV) rings bathed in a medium containing 100 mM K+ (EC50 = 47 μM, p < 0.05). These results suggest that RSV induces endotheliumindependent vasorelaxation of HUV
Summary
Dragana D Protić1*, Radmila B Novaković, Svetlana Spremović-Radjenović, Nebojša V Radunović, Helmut Heinle, Vladimir I Kanjuh, Ljiljana C Gojković-Bukarica.
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