Abstract
1018Background: The role of postmastectomy radiotherapy (PMRT) in breast cancer patients with pathologic T3N0M0 disease remains controversial. The purpose of this study was to determine the impact of PMRT on overall survival among pT3N0M0 breast cancer patients in the National Cancer Data Base (NCDB). Methods: Using the NCDB, 3,437 women diagnosed with pT3N0M0 breast cancer between 2003 and 2011 were identified. All received initial treatment with mastectomy. 1,644 (47.8%) received PMRT. Univariable and multivariable analyses (MVA) were performed to identify patient, tumor, and treatment characteristics associated with PMRT and factors predictive of overall survival (OS). Tests of interaction between PMRT and relevant variables were performed. Additionally, propensity score matching (PSM) was employed to reduce treatment selection bias. Results: On MVA, treatment with PMRT was associated with age < 40 (p = 0.02), private insurance coverage (p < 0.01), increasing tumor size (p = 0.04), use of chemotherapy ...
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