Abstract
Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed.
Highlights
Paraoxonase (PON) is one of the more important antioxidants and antiatherogenic enzymes
Proteins encoded by the Paraoxonase 1 (PON1) and PON3 are found in the blood circulation,[6] while the intracellular enzyme encoded by PON2 is not found in the circulation
The cases and controls were evaluated to determine the effects of PON1 polymorphisms on hypothyroidism, colorectal cancer, and pancreatitis susceptibility
Summary
Paraoxonase (PON) is one of the more important antioxidants and antiatherogenic enzymes. It is mainly synthesized in the liver and metabolizes organophosphate, carbamate, aromatic carboxylic acid ester, unsaturated aliphatic ester, cyclic carbonate, and lactone compounds. It plays a significant role in the detoxification of nerve gases such as sarin, soman, and tabun.[1,2,3] The PON family consists of three genes: PON1, PON2, PON3, with each encoding a unique protein. All the enzymes prevent oxidation of lipids[7,8] and are important for components of the antioxidant system in humans. Dysfunction in these enzymes can be associated with some diseases related to oxidative stress such as cancer and cardiovascular disease.[9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
