The role of polymorphism of the interferon gene ɣ and interferonoproduction in the pathogenesis of infection caused by herpes 6 type virus in children of early age.

Abstract

The purpose of the article is to reveal the immunological features of the infection caused by the herpesvirus type 6 virus, based on the level of the polymorphism IFNG geneγ (+874 A / T) and interferon production. Group I (n = 58) consisted of children with herpetic infection of type 6, severe form. Group II (n = 31) included children with herpetic infection of type 6, medium-heavy form. The control group consisted of 53 healthy newborns born. The allelic variants of the genes were determined by the PCR method followed by restriction analysis of the GosNII Genetics test systems (Moscow) Among the allelic variants of the interferon γ gene, patients with a severe form of herpetic infection of type 6 are significantly more likely than in children with a moderate-to-severe course of the disease, and the AA genotype of the polymorphism +874 of the IFNG gene is detected in the control group and significantly less than the control group, the allele T and the TT genotype. The level of interferon-γ had a significant decrease in children with severe infection in comparison with the control group. Exposure of the infection is associated with the A allele and the AA genotype of the polymorphic region +874 A / T of the IFNG gene.