The role of polymorphic loci of the cytokine gene IL6 (C174G) in inflammatory and ulcerative lesions of the stomach

Abstract

Purpose of the study. To study the distribution and role of polymorphic loci of the cytokine gene IL6 (C174G) in inflammatory and ulcerative lesions of the stomach. Material and research methods. In this study, the detection of the polymorphic IL6 gene (C174G) was carried out in patients with inflammatory and ulcerative lesions of the stomach (n=96) and healthy individuals (n=88). Results. Analysis of the features of the distribution of IL6 (C174G) gene polymorphism among the studied groups of patients with inflammatory and ulcerative diseases compared with healthy ones, its contribution to the pathogenetic mechanisms of their formation was found, which is confirmed by the presence of a pronounced tendency to increase the frequencies of the major C allele by 3.3 times (χ 2 = 3.3; P=0.1) and C/C genotype by 2.9 times (χ 2 =2.9; P=0.1) in chronic non-atrophic gastritis (CNG), as well as the minor allele G by 2.5 times (χ 2 =2.5; P=0.2) in ulcerative diseases of the stomach (GU). In addition, the contribution of the studied genetic marker is also confirmed by the presence of a tendency to increase the major allele C by 3.1 times (χ 2 =1.9; P=0.2) and the C/C genotype by 2.8 times (χ 2 =1.4; P=0.3; OR=2.8; 95%CI: 0.52-15.37) among patients with CNG compared with those in the group with chronic erosive gastritis (CEG), as well as a statistically significant increase in these indicators by 5.8 times (χ 2 =6.6; P=0.025) and 6.2 times (χ 2 = 6.3; P=0.025), respectively, in comparison with the group of patients with GU. No significant association between the likelihood of erosive chronic gastritis and C174G polymorphic loci of the IL6 gene was found compared to healthy individuals. However, compared with GU, the contribution of the major C allele and the major C/C genotype is confirmed by the presence of a trend towards their increase among patients with CEG by 1.9 (χ 2 =2.0; P=0.2) and 2.2 times (χ 2 =2.1; P=0.2). Conclusions: based on the results of the study, it can be argued that the C174G polymorphic loci of the IL6 gene play a significant role in the mechanisms of formation of inflammatory and ulcerative diseases of the stomach in Uzbekistan.