The Role of Platelet Rich Fibrin for Closure of Oronasal Fistula Post Palatoplasty through Abilities to Keep Growth Factor Activity for a Relatively Longer Period and Stimulate Tissue Regeneration Effectively

Abstract

Oronasal fistula is one of the unfortunate consequences of cleft palate surgery. This can be done after palate surgery in patients with cleft palate, defined as an abnormal connection between the oral and nasal cavities. Multiple systems have attempted that classification. It can be a small, symptomatic or asymptomatic fistula that needs correction. Its speed varies greatly depending on many factors. Both surgical and non-surgical methods (the advantages and disadvantages of each should be considered) are available for correction, and there are combination therapies that help improve surgical outcomes. Platelet-rich fibrin (PRF) is a novel Generation platelet concentrate, very easy to prepare and handle without the use of biochemicals. Its production is dependent on the accumulation of platelets that release cytokines and growth factors. Enriched with growth factors, this hemostatic plug is easy to prepare and operate. Adapted for soft and hard tissue healing. It is used in various fields of dentistry, especially oral and maxillofacial surgery. Reports on the role of PRF in repairing oronasal fistula closure are sparse in the literature, especially in relation to other soft tissue flaps.