The role of platelet mass index in the prediction of preeclampsia full

Abstract

To assess the possible roles of platelet indices including platelet mass index (PMI), platelet count (PC), mean platelet volume (MPV) and PC/MPV in prediction of preeclampsia. 190 pregnant women diagnosed with preeclampsia and 100 healthy uncomplicated control patients were included in this retrospective study. Age, gestational week, fetal weight, alanine transaminase (ALT), aspartate transaminase (AST), creatinine, blood urea nitrogen (BUN), complete blood count parameters and platelet indices were compared. ROC curve was applied to analyze the cut-off values of the significantly differing parameters for prediction of preeclampsia. Preeclamptic patients gave birth significantly earlier than the controls. In preeclamptic patients, the mean values of PC, PC / MPV and PMI were significantly lower than the control group. Although mean MPV values were lower in preeclampsia patients, the difference was not significant. The cut-off values of PC, PC/MPV and PMI were found to be 207,500, 18448.16 and 2411.75 with a-sensitivity/specificity of 45.3%/ 44.3%, 42.2%/ 42.6% and 44.1%/ 44.3%, respectively. Indices such as PC, PC / MPV and PMI changed significantly in preeclampsia. Although they have low sensitivity and specificity, these indices can be combined with other parameters and used in the prediction of preeclampsia.