The Role of Platelet Indices to Predict the Vascular Complication in Diabetic Patients in South Tamil Nadu

Abstract

Background: Diabetic patients have larger young, more reactive and more agregable platelets. Platelet indices such as Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) are the indicators of increased platelet activity and considered as potential markers for diabetic vascular complications. This study aimed to estimate and compare Platelet count, MPV and PDW between (1) Diabetics patient and Controls (2) Diabetics under glycaemic control and not under glycaemic control. Methodology: This cross sectional study was conducted at, Tirunelveli Medical College, Tamil Nadu, India, during August 2015 to September 2017. In this study 100 diabetic patients and 100 controls were included. Inclusion criteria for diabetics were FBS > 126 mg/dl, PPBS > 200 mg/dl, and age between 35-65 years. Exclusion criteria for diabetics were age less than 35 and greater than 65 years. The criteria for controls include normal FBS, PPBS levels, and age from 35-65 years and without any thromboembolic conditions. Results: Data analysis was done using SPSS 19.0. MPV was significantly increased in (a) diabetics than healthy controls (b) diabetics under glycaemic control than diabetics not under glycaemic control. PDW showed significant difference between (a) diabetics and non-diabetic controls, (b) diabetics under glycaemic control and not under glycaemic control. There was no significance of platelet count among group A and group B. P value < 0.05 was considered significant. Conclusion: In this study MPV and PDW were significantly increased in diabetic patients than non-diabetic healthy individuals and higher in diabetic patients not under glycaemic control than the diabetic under glycaemic control.