Abstract
The Role of Phosphoinositides in Signaling and Disease: Introduction to the Thematic Review Series
Highlights
Phosphoinositide metabolism is a major mechanism used by eukaryotic cells to convert their membrane surfaces into what are, in effect, high-definition signaling screens
The signaling power of phosphoinositides has been appreciated since the 1970s, these lipids continue to surprise with regard to the diverse ways they are used as intracellular signals, and how specific pools of these lipids are dedicated to particular biological outcomes
In a perhaps related matter, it is curious that the number of enzymes dedicated to synthesis and degradation of phosphoinositides is greater than the number of substrate molecules
Summary
The Role of Phosphoinositides in Signaling and Disease: Introduction to the Thematic Review Series Phosphatidylinositol is a metabolic precursor of phosphoinositides, and these lipids collectively define a major component of the eukaryotic intracellular chemical signaling program. Phosphoinositide metabolism is a major mechanism used by eukaryotic cells to convert their membrane surfaces into what are, in effect, high-definition signaling screens.
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