Abstract
The voltage-gated proton channel is a member of the voltage-gated ion channels containing voltage-sensing domains (VSDs). The VSDs are made of four membrane spanning segments (S1 through S4), and their function is to detect changes in membrane potential in the cells. A highly conserved phenylalanine (Phe) is located in the S2 segment of the voltage-gated ion channel and acts as a “gating charge transfer center”. In the voltage-gated shaker K+ channel, the large side chain of the conserved Phe was crucial to stabilize the depolarized VSD conformation.
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