Abstract
Background Prostaglandin E2 plays a crucial role in inflammation, including pain, fever and tumorigenesis. Inflammatory cells, fibroblasts and epithelium are the main source of PGE2 throughout an immune response. There are four known receptors for PGE2, E type prostanoid receptors 1–4 (EP1,2,3,4). According to recent reports, the EP4 receptor seems to be a potential target of therapeutic treatment for attenuating inflammation as well as increased endothelial permeability.
Highlights
Prostaglandin E2 plays a crucial role in inflammation, including pain, fever and tumorigenesis
The pulmonary microvascular endothelial cells express the PGE2 receptor EP4, which was shown by flow cytometry and Western blotting
EP4 receptor protein expression was down-regulated to less than 40% by using the siRNA transfection approach
Summary
The role of PGE2 EP4 receptors in the regulation of endothelial barrier function. From 18th Scientific Symposium of the Austrian Pharmacological Society (APHAR).
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