Abstract

Background: Gastric cancer is one of the most common and leading causes of cancer death worldwide, with an increasing risk and prevalence. Although the usage of 18-FDG PET-CT in gastric cancer evaluation remains a matter of debate and is not consistently recommended by international guidelines, our descriptive review aims to highlight its actual role in the diagnostic accuracy, staging, therapeutic management, and relapse monitoring of this malignancy.
 Methods: The current research was conducted using scholarly databases including PubMed, Scopus, and Google Scholar by searching useful science journals, references, and abstracts on the topic. The keywords used were “gastric cancer” AND “PET-CT”.
 Results: 18-FDG PET-CT remains a promising method with increasing clinical utility not only across a wide variety of malignancies, but also among gastric cancer patients.
 Conclusions: We are certain that with further improvements, this technique could improve the diagnosis and evaluation of gastric cancer, and make it more approachable and accurate.
 Keywords
 gastric cancer (GC), PET-CT, 18-FDG PET-CT, 18F-FDG uptake, ceCT (contrast-enhanced CT)

Highlights

  • Gastric cancer is one of the most common and leading causes of cancer death worldwide, with an increasing risk and prevalence

  • Among studies, when using 18F-FDG-Pet alone for the detection of primary lesion, the sensitivity rate ranges between 58 and 94% and the specificity, ranges between 78 and 100%. When it comes to early gastric cancer (EGC), it has been noticed that the detection rate might be even lower: in EGC, only the intestinal type could be detected with 18F-FDG-positron emission tomography (PET) [8]

  • In a study which investigated a group of 31 patients (24 M; 7 F; mean age: 58.9 ± 12.6 years) for primary staging of gastric cancer during one year, primary tumor was detected in 20 patients by 18F-FDG PET-computed tomography (CT) and in 23 patients with ceCT [9]

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Summary

Introduction

Gastric cancer is one of the most common and leading causes of cancer death worldwide, with an increasing risk and prevalence. How to cite this article: CT in Gastric Cancer — Raluca-Ioana Dascălu, Dan A Narrative Review,” Sudan Nicolae Journal. Raluca-Ioana Dascălu et al the lowest rates in the United States and Western Europe [1]. In Western countries, survival rates seem to increase progressively, and in Japan, due to the routine screening programs and the focused management of prognosis-related factors, it seems to be the highest [3]. The usage of 18-FDG PET-CT in gastric cancer evaluation remains a matter of debate and is not consistently recommended by international guidelines, our descriptive review aims to highlight its actual role in the diagnostic accuracy, staging, therapeutic management, and relapse monitoring of this malignancy. Results: 18-FDG PET-CT remains a promising method with increasing clinical utility across a wide variety of malignancies, and among gastric cancer patients. Conclusions: We are certain that with further improvements, this technique could improve the diagnosis and evaluation of gastric cancer, and make it more approachable and accurate

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