Abstract
Abstract It is important to emphasize that the nerve biopsy is not a screening test for neuropathy. We have other methods of screening that are less invasive, less expensive, and less likely to produce discomfort that persists for weeks to months. Therefore, the nerve biopsy should be strategic and well planned, not a routine part of the evaluation of every neuropathy patient. The nerve biopsy is used to address specific questions, with the realization that there are limitations of interpretation imposed by the narrow range of pathological responses to a variety of insults. It is also an expensive test, employing multiple means of analysis, including paraffin, frozen and plastic (epoxy resin) embedding techniques, along with teased nerve fiber preparations; preparing the latter, in particular, takes considerable time and skill. Each of the processing methods targets different potentially affected components of the nerve. In some cases, explicit diagnostic information can be derived, in others only supportive diagnostic information can be expected.
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