Abstract
Two invasive tests are mainly used to select patients affected by NPH for surgery: measuring resistance to CSF outflow and Tap Test. Cerebral blood flow (CBF) have been demonstrated to be reduced in iNPH patients, mainly in basal ganglia (BG) and periventricular white matter (PVWM) regions. Perfusion MRI might be of value as a diagnostic and predictive tool. The rule of diffusion MRI in determining brain damage in PVWM and BG areas have been investigated. The aim of this study is to identify relationship between cerebral perfusion and microstructural damage of brain tissue measured by perfusion and diffusion MRI in PVWM and BG areas before and after tap-test and after sugery in patients who underwent VP shunt.
Highlights
Two invasive tests are mainly used to select patients affected by NPH for surgery: measuring resistance to CSF outflow and Tap Test
Regions of interest were located in periventricular white matter (PVWM) and basal ganglia (BG) areas
Patients have been divided into two groups: the first cohort that improved after Tap test, and the second one that did not
Summary
Two invasive tests are mainly used to select patients affected by NPH for surgery: measuring resistance to CSF outflow and Tap Test. Methods 23 patients were included in this study. MRI related rCBF and apparent diffusion coefficient (ADC) were calculated in all the cases.
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