Abstract
Background: Patent foramen ovale (PFO) closure has been compared to medical therapy for secondary prevention of recurrent cryptogenic stroke. Objectives: To produce an updated meta-analysis including only data from the primary analyses of clinical trials and to evaluate the role of PFO closure in the secondary prevention of recurrent stroke. Methods: Search in Medline (PubMed) and in ISI Web of Knowledge. Parameters under analysis and meta-analyses were: stroke, transient ischemic attack (TIA) and atrial fibrillation (AF). Comprehensive Meta-analysis Software V.2.0 [...]
Highlights
Stroke remains one of the most important causes of death and morbidity worldwide.[1]
Forty to fifty percent of patients who suffer a cryptogenic stroke have a patent foramen ovale (PFO). This association suggests that some cryptogenic strokes, in younger patients, may be due to paradoxical embolism, which consists in the passage of a thrombus from the venous to the atrial system through a patent foramen ovale.[3,4]
Controversy has persisted after the first reports were published on whether Patent foramen ovale (PFO) closure reduces the risk of recurrent stroke for patients with cryptogenic stroke and documented PFO, when compared with medical therapy
Summary
Stroke remains one of the most important causes of death and morbidity worldwide.[1]. The options to implement secondary prevention of recurrent stroke for patients with a patent foramen ovale who have had a cryptogenic stroke have been the administration of antithrombotic medications or percutaneous closure of PFO. It was not initially clear whether percutaneous closure is superior to medical therapy.[5,6] The results of early studies gave. Conclusions: In patients with cryptogenic stroke who had a patent foramen ovale, a protective effect of closure was seen concerning the risk of recurrent stroke, but not regarding the prevention of TIA. Conclusions: In patients with cryptogenic stroke who had a patent foramen ovale, a protective effect of closure was seen concerning the risk of recurrent stroke, but not regarding the prevention of TIA. (Int J Cardiovasc Sci. 2020; 33(4):307-317) Keywords: Foramen Ovale Patent/Diagnosis; Stroke; Isquemic Attack, Transient; Atrial Fibrillation; Risk Factors; Stroke/Prevention and control
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