Abstract
Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.
Highlights
Particle irradiation is suitable for resistant histologies, owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer (LET) radiation
adenoid cystic carcinoma (ACC) and MM are notably rare diseases, and the paucity of cases with geographical and demographic biases limits the generalizability of definitive treatment data
Direct comparison between the different types of particles is impractical given the limited availability of centers treating with carbon-ion radiotherapy (CIRT) and neutron therapy
Summary
Particle irradiation is suitable for resistant histologies, owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer (LET) radiation. 20 patients with primary sphenoid malignancies were reported, including 7 patients with ACC treated with a median 76.4 GyE; 2-year LC was 86% [15]. In 2004, the University of Heidelberg reported the early results of 21 patients treated with combination photon and carbon-ion radiotherapy (CIRT) for unfavorable ACC.
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