The role of paraoxonase in the formation of atherosclerotic changes in the vessels of patients with antiphospholipid syndrome

Abstract

As a result of studies carried out by the authors a significant reduction of the serum paraoxonase activity in a Ukrainian population of patients with antiphospholipid syndrome (APS) has been demonstrated. The main factors that affect the enzyme level were the male gender, age, arterial hypertension, tobacco smoking, abnormalities of lipid metabolism. The course of the disease and obesity did not play a significant role. Cause-and-effect relationships between a low enzymatic activity in patients with APS and the presence of high titers of anticardiolipin antibodies and beta-2 glycoprotein 1 antibodies has been established. A reduction of paraoxonaze level is a predictor of an early development of structural and functional changes in the blood vessels of patients with APS.