Abstract
AbstractThe normal function of the retina is crucially dependent on an adequate perfusion and oxygenation of the tissue. Thus, it does not come as a surprise that ocular blood flow is very well autoregulated. It is known for a long time that the retinal circulation, and to some extent also the chorodial circulation can compensate for changes in ocular perfusion pressure in order to keep blood flow constant. This is usually referred to as an autoregulatory response of these vascular beds. However, the ocular circulation also responds to changes in oxygen tension. For example, breathing of pure oxygen leads to a pronounced vasoconstriction of the retinal vessel, indicating that the ocular circulation also adapts to changes in oxygen tension. This talk aims to summarize our current evidence of the role of oxygen in ocular blood flow regulation and how this may relate to ocular pathologies such as glaucoma or diabetic retinopathy.
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