The role of oxidative stress in the pathogenesis of pre-eclampsia.

Abstract

Exclusively occurred during pregnancy, preeclampsia causing complex multisystem disorders that lead to maternal and fetal mortality and morbidity. The major burden in discovering pathogenesis of preeclampsia is still widely noticed. Oxidative stress believed to be one of the major causalin its pathophysiology. Its role on reducing blood perfusion thorugh ischemia results on abnormal placentation. Dysfunction assumed to be caused by oxidative damage and antioxidant defence imbalance as it becoming a central feature in the pathophysiology of preeclampsia. This pathway is widely studied and acknowledged recent years.