The role of oxidative stress in bipolar disorder: Is DNA damage a potential biomarker of disease severity?

Abstract

Event Abstract Back to Event The role of oxidative stress in bipolar disorder: Is DNA damage a potential biomarker of disease severity? Lai Fong Chan1*, Jiann Lin Loo1, 2, Jo Ann Goon3, Nurul Ain Mohamad Kamal1, Hanafi Damanhuri3, Nor Azian Abdul Murad4, Mohd Shazrul Fazry Sa'Ariwijaya5, Shalisah Sharip1, Suriati Mohd Saini1, Geetha Gunasekaran3, Thambu Maniam1, A. Rahman A. Jamal4 and Wan Zurinah Wan Ngah3 1 UKMMC, Dept of Psychiatry, Faculty of Medicine, Malaysia 2 UMS, Dept of Psychiatry, Faculty of Medicine, Malaysia 3 UKMMC, Dept of Biochemistry, Faculty of Medicine, Malaysia 4 UKM, UMBI, Malaysia 5 UKM, School of Biosciences & Biotechnology, Faculty of Science & Technology , Malaysia There is accumulating evidence of bipolar disorder as a neuroprogressive disease associated with oxidative stress and inflammatory processes. Oxidative stress markers have been associated with the depressive phase and suicide attempts in bipolar disorder. However, the specificity and clinical utility of such “biomarkers” are still inconclusive. Our study aims to determine the association between DNA damage and clinical parameters i.e. severity of depression, lifetime suicidal ideation, behavioural impulsivity and life event changes in patients diagnosed with bipolar disorder. A cross-sectional sample of twenty five patients diagnosed with bipolar disorder based on the M.I.N.I. Neuropsychiatric Interview in the National University of Malaysia Medical Centre were assessed for depression severity (Quick Inventory of Depressive Symptomatology, QIDS), behavioural impulsivity (Barratt Impulsivity Scale, BIS), lifetime suicidal ideation (Columbia Suicide Severity Rating Scale, C-SSRS), change in life events (Social Readjustment Rating Scale, SRRS) and DNA damage using a standard protocol for comet assay. Pearson correlation test showed a significant association between severe DNA damage and a higher total QIDS score (p=0.04). Age (p=0.320), gender (p=0.966), ethnicity (p=0.283), lifetime suicidal ideation (p=0.363), total SRRS score (p=0.860) and total BIS score (p=0.434) were not significantly associated with severe DNA damage in our preliminary sample of 25 bipolar patients. Our study showed preliminary evidence of a significant association between severe DNA damage and higher severity of depression in patients with bipolar disorder. Future larger prospective studies are warranted to confirm this finding in order to elucidate possible oxidative stress mechanisms underlying bipolar disorder. Such findings have potential implications on new targets of drug discovery for bipolar depression. Keywords: Bipolar Disorder, Depression, DNA Damage, Oxidative Stress, Clinical parameter Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Poster Presentation Session Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Chan L, Loo J, Goon J, Mohamad Kamal N, Damanhuri H, Abdul Murad N, Fazry Sa'Ariwijaya M, Sharip S, Mohd Saini S, Gunasekaran G, Maniam T, A. Jamal A and Wan Ngah W (2016). The role of oxidative stress in bipolar disorder: Is DNA damage a potential biomarker of disease severity?. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00133 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Lai Fong Chan, UKMMC, Dept of Psychiatry, Faculty of Medicine, Cheras, Kuala Lumpur, Malaysia, laifchan@ppukm.ukm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lai Fong Chan Jiann Lin Loo Jo Ann Goon Nurul Ain Mohamad Kamal Hanafi Damanhuri Nor Azian Abdul Murad Mohd Shazrul Fazry Sa'Ariwijaya Shalisah Sharip Suriati Mohd Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah Google Lai Fong Chan Jiann Lin Loo Jo Ann Goon Nurul Ain Mohamad Kamal Hanafi Damanhuri Nor Azian Abdul Murad Mohd Shazrul Fazry Sa'Ariwijaya Shalisah Sharip Suriati Mohd Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah Google Scholar Lai Fong Chan Jiann Lin Loo Jo Ann Goon Nurul Ain Mohamad Kamal Hanafi Damanhuri Nor Azian Abdul Murad Mohd Shazrul Fazry Sa'Ariwijaya Shalisah Sharip Suriati Mohd Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah PubMed Lai Fong Chan Jiann Lin Loo Jo Ann Goon Nurul Ain Mohamad Kamal Hanafi Damanhuri Nor Azian Abdul Murad Mohd Shazrul Fazry Sa'Ariwijaya Shalisah Sharip Suriati Mohd Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.