Abstract
Guinea-pig subcutaneous chambers were infected with a mixture of gonococcal variants of defined outer membrane protein profile. Survival within the chambers was a two-stage process. The initial advantage conferred by the lack of opacity-related outer membrane protein was transient and survivors were replaced by opaque colonial variants. Amongst these survivors were variants which produced opacity-related proteins (IId, IIe and IIf) not present in the initial inoculum. Thus, outer membrane protein composition is an important factor in survival in vivo.
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