Abstract
Our previous data demonstrated mouse GnRH (mGnRH) gene promoter activity in ovarian granulosa cells as well as in hypothalamic neurons. We also identified two binding sites for Otx2, between -356 bp and -249 bp, in the mouse GnRH gene promoter. Our objective was to determine whether binding of Otx2, a homeodomain transcription factor, to these sites in the mouse GnRH gene promoter has a role in the differential expression of neuronal and ovarian GnRH in vivo.
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