The role of opioid processes in reward and decision-making.

Abstract

Contemporary theories emphasize the involvement of the endogenous opioid system in assigning hedonic values to rewards. Although earlier research supports this view, recent findings suggest that opioids play a larger and more complex role in reward processes than these theories suggest. For example, opioid activity in the basolateral amygdala is required for encoding incentive learning, a process by which the value of goal-directed actions is updated. Outside the amygdala, opioid receptors in the ventral striatum have been found to promote choice between different courses of action. Specifically, μ opioid receptors in the nucleus accumbens core and δ opioid receptors in the nucleus accumbens shell have been reported to mediate distinct aspects of incentive motivation; the core regulating the effect of experienced reward and the shell of predicted reward on choice. In both cases, the involvement of opioid receptors was restricted to the time of choice, although changes in their expression pattern could be observed prior to that point. This time-restricted involvement of opioid receptor-related processes is consistent with the view that opioids in the nucleus accumbens are central components of the limbic-motor interface, integrating reward-related information with instrumental learning to guide decision-making, particularly the selection and execution of goal-directed actions. This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2.