The role of one-hour post-load hyperglycemia in prediction and prevention of type 2 diabetes

Abstract

One-hour post-load glucose concentration (1hPG) ≥155 mg/dl (8.6 mmol/L) in individuals with normal glucose tolerance (NGT) was correlated with increased risk for type 2 mellitus. This paper is the Chinese translation One-hour post-load hyperglycemia: implications for prediction and prevention of type 2 diabetes , published on The Journal of Clinical Endocrinology & Metabolism [Fiorentino TV, Marini MA, Succurro E, et al. J Clin Endocrinol Metab, 2018, 103(9): 3131-3143] after obtaining the copyright of the original journal. In this review, the authors analyzed the role of 1hPG measurement in prediction of type 2 and cardiovascular disease. They used MEDLINE and included all English studies published up to February 2018 in peer-reviewed journals that examined the relationship between 1hPG and diabetes, cardio-metabolic alterations, organ damage, and cardiovascular disease. The results showed that although 1hPG was not adopted by American Diabetes Association for identifying high-risk individuals, the available evidence indicated that, among subjects with NGT, a value of 1hPG≥155 mg/dl is helpful to identify those at increased risk of type 2 and cardiovascular disease. (Chin J Endocrinol Metab, 2018, 34: 1060-1066) Key words: 1-h post-load glucose concentration; Diabetes mellitus, type 2; Blood-derived biomarkers