Abstract
<p indent="0mm">O-GlcNAc modification of protein is an important post-translational modification and catalyzed by O-GlcNAc transferase (Ogt). O-GlcNAcylation is involved in many biological processes and closely related to many diseases via regulating the function of proteins. O-GlcNAc modification is widespread in nervous system and displays dynamic feature during development and aging. Previous studies have shown that O-GlcNAc modificaition plays an important role in regulating embryonic and adult neurogenesis, neuronal maturation, survival and synaptic development, and mouse cognitive ability. In multiple neurodevelopmental and neurodegenerative diseases, O-GlcNAc modification levels of many key proteins are significantly altered. In this review, we have summarized the function and molecular mechanism of O-GlcNAc modification in neurodevelopment, aging and neurological diseases.
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