The role of nuclear factor kappa B and vascular cell adhesion molecule-1 in renal disease

Abstract

Nuclear factor kappa B (NF-κB) is an important nuclear transcription factor involved in a wide range of inflammatory mediators,adhesion molecules,chemokines and inflammatory-related enzymes in gene regulation,causing immune damage.Vascular cell adhesion molecule-1 (VCAM-1),an adhesion molecule,belongs to the immunoglobulin superfamily and can mediate adhesion of inflammatory cells and endothelial cells caused by inflammatory injury.VCAM-1 gene promoter region contains a series of many of the features of NF-κB site.NF-κB activation can increase the expression of VCAM-1 that causes the immune and inflammatory injury.Present study has found that immune inflammation is the basis of a variety of renal diseases.NF-κB,VCAM-1 in kidney disease and its research progress may be discussed in this article. Key words: Nuclear factor kappa B; Vascular cell adhesion molecule-1 ; Kidney disease