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Abstract
Bone diseases are the leading causes of disability and severely compromised quality of life. Neuropeptide Y (NPY) is a multifunctional neuropeptide that participates in various physiological and pathological processes and exists in both the nerve system and bone tissue. In bone tissue, it actively participates in bone metabolism and disease progression through its receptors. Previous studies have focused on the opposite effects of NPY on bone formation and resorption through paracrine modes. In this review, we present a brief overview of the progress made in this research field in recent times in order to provide reference for further understanding the regulatory mechanism of bone physiology and pathological metabolism.
Highlights
The mammalian skeleton is a vital organ formed by several bone types, and it is the place for hematopoiesis and mineral storage, with powerful self-repair ability and mineralized extracellular matrix
We focus on the effects of neuropeptide Y (NPY) on bone metabolism in some physiological and pathological states
Previous studies have verified that NPY is widely present in the brain and bone tissue and strongly influences bone metabolism through direct and indirect manner
Summary
The Role of NPY in the Regulation of Bone Metabolism. Neuropeptide Y (NPY) is a multifunctional neuropeptide that participates in various physiological and pathological processes and exists in both the nerve system and bone tissue. In bone tissue, it actively participates in bone metabolism and disease progression through its receptors. Previous studies have focused on the opposite effects of NPY on bone formation and resorption through paracrine modes. We present a brief overview of the progress made in this research field in recent times in order to provide reference for further understanding the regulatory mechanism of bone physiology and pathological metabolism
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