Abstract
Sedative-like Rauwolfia alkaloids lower the content of 5-hydroxytryptamine and noradrenaline in brain and other tissues. Benzoquinolizine derivatives lacking an indole group have a similar effect upon these amines. A difference in these two classes of compounds was found when the latter substances produced a short sedative effect and brief depression of the amines. In general the results suggest a causal relation between the pharmacological action of the two types of drugs upon the central nervous system and monoamine metabolism. Studies with other benzoquinolizine compounds show a differential effect upon the two amines so that noradrenaline depletion may cause sedation. Reserpine-like drugs do not have identical effects upon brain and peripheral amines. It is possible that tranquilizing effects are exerted through depletion of noradrenaline or its precursors or of other substances yet unknown.
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