Abstract
In recent years, emerging evidence has suggested that noncoding RNAs (ncRNAs) participate in nearly every aspect of biological processes and play a crucial role in the genesis and progression of numerous tumors, including B-cell lymphoma. The exploration of ncRNA dysregulations and their functions in B-cell lymphoma provides new insights into lymphoma pathogenesis and is essential for indicating future clinical trials and optimizing the diagnostic and therapeutic strategies. In this review, we summarize the role of ncRNAs in B-cell lymphoma and discuss their potential in clinical applications.
Highlights
B-cell lymphomas are a group of B-cell neoplasms with distinct natural histories and clinical behaviors
A study reported that the silencing of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in diffuse large B-cell lymphoma (DLBCL) cell lines led to increased cell apoptosis through reducing Phosphoinositide 3-kinase (PI3K)/Protein kinase B (Akt) activation [56]. lncRNA Taurine upregulated 1 (TUG1), which is overexpressed in DLBCL, affects PI3K/Akt signaling through interacting with MET and reducing its ubiquitination [48]
Recent-year studies have revealed a correlation between Non-coding RNA (ncRNA) dysregulation and abnormal B-cell receptor (BCR) signaling in B-cell lymphomas [172]. miR-150 has been confirmed to target Grb2-associated binder 1 (GAB1) and forkhead box P1 (Foxp1) in normal B cells and several B-cell lymphomas [23, 75, 75]
Summary
B-cell lymphomas are a group of B-cell neoplasms with distinct natural histories and clinical behaviors. A recent study identified a group of c-Myc-induced lncRNAs, which were differentially expressed in BL patient samples compared with normal GC B cells [72]. Studies showed NF-kB knockdown reduces miR-21 level in B-cell lymphoma, suggesting that deregulated NF-kB may lead to the increased expression of miR-21 [146].
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