Abstract
<p indent="0mm">Non-coding RNA plays an important role in all kinds of processes of life activities by its complex RNA regulatory network. More and more studies have proved that non-coding RNA can regulate carcinogenesis and progression by affecting the growth, metastasis, apoptosis, metabolism, and immune escape of tumor cells at the epigenetic, transcriptional and post-transcriptional level. In addition, non-coding RNA has been proved to be differentially expressed in a variety of malignant tumors and has the potential to be a good biomarker. This review summarized the role of non-coding RNA in different aspects of tumorigenesis and development, and introduced the application prospect of non-coding RNA in liquid biopsy and chemoresistance. It is believed that non-coding RNA, as an important regulator of cell life activities, should have more in-depth research and valuable clinical application in the future.
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