Abstract
To investigate the role of the N-methyl- d-aspartate (NMDA) receptor in the vestibular periphery, vestibular compensation in the guinea pig was studied following chemical unilateral labyrinthectomy by osmotic pump administration of streptomycin sulfate (SM) with or without d-2-amino-5-phosphonovalerate ( d-APV), one of the NMDA receptor antagonists. All animals administrated SM (SM group) or SM and d-APV (SM+ d-APV group) showed spontaneous nystagmus and head tilt. The maximum degree of yaw head tilt in the SM+ d-APV group was statistically smaller than that in the SM group. Moreover the time constant for head tilt in the SM+ d-APV group was statistically shorter than that in the SM group. These results indicate that the NMDA receptor in the vestibular periphery influences vestibular compensation after unilateral labyrinthectomy.
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