Abstract
Question: NIK knockout mice have been shown to be resistant in the mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). As the knockout mice harbor various deficiencies in the immune cell compartment as well as in the structure of lymphoid tissue, it is not possible to use them to study the cell-specific role of NIK. Of special interest is the analysis of the function of NIK in T-cells, which are one of the main players in this disease. To overcome this issue, we generated a conditional NIKfl/fl mouse where we can analyze the role of NIK specifically in T-cells in the pathogenicity of EAE.
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