The role of neuron specific enolase for endocrine ophthalmopathy and the formation of optic neuropathy

Abstract

Aim . The aim of this work was to study the role of the neuron specific enolase during the endocrine ophthalmopathy and the formation of optic neuropathy. Materials and methods . The study 42 patients with EOC at the age of 41 (30; 47) years. It was 9 males (21%). The control group consisted of 15 healthy individuals matched by sex and age. The object of the study of blood serum and tear fluid. Measurement of NSE level was measured by ELISA CanAgNSEEJA. All persons included in the study was performed optical coherence tomography (OCT), ophthalmoscopes, perimetry. Statistical analysis of the data using the program Statistics 6.1. Results. An increase in the concentration of NSE in serum and lachrymal fluid of patients with endocrine ophthalmopathy, compared to healthy subjects. It should be noted that the increase in concentration of the test marker was associated with disease severity - more severe cases, accompanied by a large concentration of NSE. In severe IC-threatening loss of the highest concentration of NSE detected in blood serum and in the tear fluid. Conclusion . An increase in the concentration of NSE in patients with IC in the blood to a greater extent in the tear fluid, depending on the severity o f the IC. These studies allow the NSE to regard as an early marker of neuronal tissue damage GO, before the typical clinical and instrumental signs of optic neuropathy.