The role of neoadjuvant polychemotherapy in the treatment of patients with stage IIB cervical cancer

Abstract

Introduction and Aim: More than 85% of cervical cancer (CC) cases are reported in developing countries where access to screening is limited. With localized forms of CC, it is possible to achieve good treatment results using radical procedures compared to locally widespread processes. Methods: This is a retrospective study of 68 patients with stage IIB CC hospitalized from 2013–2022. During the initial treatment and after a full clinical examination, all patients were diagnosed with stage IIB CC, a parametrial and vaginal involvement. Results: Forty-six patients (74%) received two courses of chemotherapy, 14 patients (23%) received three courses, and 2 patients (3%) received four courses. The tumor became resectable after two courses in 46 patients, after 3–4 courses all patients moved on to the next surgical stage. Of the early postoperative complications, 9 patients (14.5%) had bladder atony, which was resolved by the conservative method. Conclusion: Thus, there is a certain category of patients with CC, where it is possible to make the tumor into a resectable form, and this will increase the percentage of the surgical component of treatment, which in turn could increase the 5-year disease-free survival rates of patients with stage IIB CC.