Abstract
Neuronal growth regulator 1 (NEGR1) is a membrane raft‐associated protein, which has been spotlighted as a new locus related to human obesity. We previously identified that NEGR1 interact with Niemann‐Pick diseases, type C2 (NPC2) that plays a key role in intracellular cholesterol trafficking, suggesting a new role of NEGR1 in the intracellular lipid transport. In this study, we report that the level of lipid droplets (LD) reduced in NEGR1‐overexpressiong 3T3L‐1 cells compared to vector‐transfected controls. Moreover, we observed that the intracellular LD level was higher in primary adipocytes obtained from NEGR1−/− mice than those from wild‐type mice. In addition, the expression level of LD‐associated protein, perilipin‐2/ADRP, increased in white adipose tissues of NEGR1‐deficient mice, although we could not detect any direct interaction between NEGR1 and ADRP proteins. Altogether, we suggest that NEGR1 is involved in LD formation possibly by regulating the intracellular lipid trafficking.Support or Funding InformationKorea research foundation
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